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Role of Biomaterials and Controlled Architecture on Tendon/Ligament Repair and Regeneration

Young Jung No, Miguel Castilho, Yogambha Ramaswamy, Hala Zreiqat

Published: 01/05/2020

Abstract

Engineering synthetic scaffolds to repair and regenerate ruptured native tendon and ligament (T/L) tissues is a significant engineering challenge due to the need to satisfy both the unique biological and biomechanical properties of these tissues. Longā€term clinical outcomes of synthetic scaffolds relying solely on high uniaxial tensile strength are poor with high rates of implant rupture and synovitis. Ideal biomaterials for T/L repair and regeneration need to possess the appropriate biological and biomechanical properties necessary for the successful repair and regeneration of ruptured tendon and ligament tissues.

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