Notch-Rho-cGMP interaction: common point of convergence in microvascular aging-related disease

Anton J.M. Roks, Caroline Cheng, Catherine M. Shanahan

Published: 28 May 2021


Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3-Rho kinase-cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.

Full Access Link: Clinical science (London, England : 1979)