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Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

Laura Rijns, Lu Su, Konrad Maxeiner, Giulia Morgese, David Y. W. Ng, Tanja Weil and Patricia Y. W. Dankers

Published: 2023

Abstract

Benzene-1,3,5-tricarboxamide (BTA) glyco-monomers containing one, two or three mannose units are synthesized and formulated into differently patterned supramolecular glycopolymers through homo-assembly or co-assembly with non-functionalized BTAs. Unfortunately, no cellular activity could be detected. Excitingly, these glyco-BTA monomers could be formulated into hydrogels, paving the way for (immune) cell culture.

Graphical abstract: Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

Full Access Link: Chemical Communications