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Engineered protein cages for selective heparin encapsulation

Salla Välimäki, Qing Liu, Lise Schoonen, Daan F. M. Vervoort, Nonappa, Veikko Linko, Roeland J. M. Nolte, Jan C. M. van Hest and Mauri A. Kostiainen

Published: 7 February 2021

Abstract

A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

Graphical abstract: Engineered protein cages for selective heparin encapsulation

Full Access Link: Journal of Materials Chemistry B