Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Eva Magdalena Estirado, Bas J. H. M. Rosier, Tom F. A. de Greef and Luc Brunsveld

Published: 28/05/2020


Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanoscaffold concentration. The modularity of the system allows for dynamic regulation of enzyme activity through variation of the recruitment-motif density along the supramolecular polymer.

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