Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart

Sandrine Lecour, Bastiaan C Du Pré, Hans Erik Bøtker, Bianca J J M Brundel, Andreas Daiber, Sean M Davidson, Peter Ferdinandy, Henrique Girao, Can Gollmann-Tepeköylü, Mariann Gyöngyösi, Derek J Hausenloy, Rosalinda Madonna, Michael Marber, Cinzia Perrino, Maurizio Pesce, Rainer Schulz, Joost P G Sluijter, Sabine Steffens, Sophie Van Linthout, Martin E Young, Linda W Van Laake

Published: 20 September 2022


Circadian rhythms are internal regulatory processes controlled by molecular clocks present in essentially every mammalian organ that temporally regulate major physiological functions. In the cardiovascular system, the circadian clock governs heart rate, blood pressure, cardiac metabolism, contractility, and coagulation. Recent experimental and clinical studies highlight the possible importance of circadian rhythms in the pathophysiology, outcome, or treatment success of cardiovascular disease, including ischaemic heart disease. Disturbances in circadian rhythms are associated with increased cardiovascular risk and worsen outcome. Therefore, it is important to consider circadian rhythms as a key research parameter to better understand cardiac physiology/pathology, and to improve the chances of translation and efficacy of cardiac therapies, including those for ischaemic heart disease. The aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to highlight key aspects of circadian rhythms to consider for improvement of preclinical and translational studies related to ischaemic heart disease and cardioprotection. Applying these considerations to future studies may increase the potential for better translation of new treatments into successful clinical outcomes.

Full Access Link: Cardiovascular research