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A Revised Modular Approach to (–)-trans-Δ 8 -THC and Derivatives Through Late-Stage Suzuki–Miyaura Cross-Coupling Reactions

Victor R. L. J. Bloemendal, Daan Sondag, Hidde Elferink, Thomas J. Boltje, Jan. C. M. van Hest, Floris P. J. T. Rutjes

Published: 31/03/2019

Abstract

A revised modular approach to various synthetic (–)‐trans ‐Δ8‐THC derivatives is disclosed. Ten derivatives were sythesized using both sp2‐ and sp3‐hybridized fragment couplings.

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Full Access Link: European Journal of Organic Chemistry