Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses

05/01/2024 Article

Simonides Immanuel van de Wakker, 1 Julia Bauzá‐Martinez, 2 Carla Ríos Arceo, 1 Herak Manjikian, 1 Christian Jamie Bernard Snijders Blok, 1 Marieke Theodora Roefs, 1 Eduard Willms, 3 Renee Goverdina Catharina Maas, 1 Matti Feije Pronker, 2 Olivier Gerrit de Jong, 4 Wei Wu, 2 , 5 , 6 André Görgens, 7 , 8 Samir El Andaloussi, 7 Joost Petrus Gerardus Sluijter, 1 and Pieter Vader 1 9

Cardiac progenitor cell (CPC)‐derived small extracellular vesicles (sEVs) exhibit great potential to stimulate cardiac repair. However, the multifaceted nature of […]

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Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease

28/12/2023 Article

Fjodor A Yousef Yengej 1, Carla Pou Casellas 1, Carola M E Ammerlaan 1, Charlotte J A Olde Hanhof 2, Emre Dilmen 2, Joep Beumer 3, Harry Begthel 4, Elise M G Meeder 5, Joost G Hoenderop 2, Maarten B Rookmaaker 6, Marianne C Verhaar 7, Hans Clevers 8

Organoid technology is rapidly gaining ground for studies on organ (patho)physiology. Tubuloids are long-term expanding organoids grown from adult kidney […]

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Effect of Mechanical Stimuli on the Phenotypic Plasticity of Induced Pluripotent Stem-Cell-Derived Vascular Smooth Muscle Cells in a 3D Hydrogel

30/11/2023 Article

Elana M. Meijer, Rachel Giles, Christian G.M. van Dijk, Ranganath Maringanti, Tamar B. Wissing, Ymke Appels, Ihsan Chrifi, Hanneke Crielaard, Marianne C. Verhaar, Anthal I.P.M. Smits, Caroline Cheng

Introduction Vascular smooth muscle cells (VSMCs) play a pivotal role in vascular homeostasis, with dysregulation leading to vascular complications. Human induced […]

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Bisurea-Based Supramolecular Polymers for Tunable Biomaterials

30/11/2023 Article

Marle E J Vleugels 1 2, Rik Bosman 1 2, Piers H da Camino Soligo 1 2, Stefan Wijker 1 2, Bence Fehér 3 2, A J H Spiering 1 3 2, Laura Rijns 4 2, Riccardo Bellan 4 2, Patricia Y W Dankers 4 2, Anja R A Palmans 1 2

Water-soluble supramolecular polymers show great potential to develop dynamic biomaterials with tailored properties. Here, we elucidate the morphology, stability and […]

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Evaluation of pliable bioresorbable, elastomeric aortic valve prostheses in sheep during 12 months post implantation

14/11/2023 Article

Annemijn Vis, Bente J. de Kort, Wojciech Szymczyk, Jan Willem van Rijswijk, Sylvia Dekker, Rob Driessen, Niels Wijkstra, Paul F. Gründeman, Hans W. M. Niessen, Henk M. Janssen, Serge H. M. Söntjens, Patricia Y. W. Dankers, Anthal I. P. M. Smits, Carlijn V. C. Bouten & Jolanda Kluin

Pliable microfibrous, bioresorbable elastomeric heart valve prostheses are investigated in search of sustainable heart valve replacement. These cell-free implants recruit […]

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3D Printed Magneto-Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Models

10/11/2023 Article

Gerardo Cedillo-Servin, Ouafa Dahri, João Meneses, Joost van Duijn, Harrison Moon, Fanny Sage, Joana Silva, André Pereira, Fernão D. Magalhães, Jos Malda, Niels Geijsen, Artur M. Pinto, Miguel Castilho

This work reports the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting (MEW) […]

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