Materials driven regeneration
Project description Recapitulating kidney function in vitro by re-engineering kidney organoids Although kidney organoids have been extensively applied for studying development of both normal and diseased states of the human kidney, most current kidney organoid models do not completely recapitulate kidney functions in vitro, with generation of higher order structures involving multiple parts of native […]
Development of functional vasculature and inducing atherosclerosis-on-a-chip. Current vascular research is focusing on understanding physiological and pathological processes for therapeutic purposes and regenerative applications. A broad variety of in vitro approaches have been developed during the past years for studying fundamental and disease conditions. However, these set-ups generally either or both lack vascular geometries and/or […]
Project description Well-functioning vascular access is the fundament of carrying out efficient hemodialysis in CKD patients. Since it’s still the major cause of morbidity and high costs in those patients, there’s a need for improved techniques to provide vascular access during treatment. In this project, we aim to create a blood-vessel like structure using elektrospun […]
Project description In this project, we will explore the ethical aspects of intelligent, life-like materials, and look into the ethical questions that arise in the fields of biomaterial science, tissue engineering and regenerative medicine. To map the field, we will start out with a systematic literature review of the ethical implications of tissue engineering for […]
Project description Functional biomaterials are often used in new medical treatment strategies and particularly, research towards synthetic ECM mimics has gained great interest. However, small changes in material composition could lead to much more pronounced differences in material properties. Therefore, automatization of biomaterial screening may be a remunerative approach. The aim of this work is […]
Project description The aim of this project is to combine bioceramic-based nanoparticles and 3-dimensional porous scaffolds to create a composite with bifunctional effects including anti-cancer and bone tissue regeneration for curing bone defects caused by tumor tissues. Bone, unfortunately, due to its special microenvironment, can be induced to cause tumor mutation (primary bone tumor) and […]
Project description The aim of this work is to develop and enhance electrospun scaffolds for an in vitro model of the nephron, using iPSCs and adult stem cells-derived vascular organoids. Furthermore, new 3D printing techniques will be developed to allow guided fractal branching of macro vessels to recreate the connections to the capillary bed of […]
Project description Ideally, tissue injury gets resolved quickly and effectively; wound healing and repair succeed the acute inflammatory phase and tissue function is restored. However, the outcome after tissue injury is dependent on multiple factors including the tissue location, the internal milieu of the host such as reno-cardiovascular disease and age. When the response to […]
Project description All tissues in the human body need to be vascularized to provide oxygen and nutrients to the cells and remove waste metabolites. This is immediately the bottleneck of tissue engineering, larger constructs need to be vascularized. The current challenge is not only the co-culture of the vasculature and the tissue of interest, both […]