Six research projects received funding this month within the Open Technology Programme (OTP). The board of NWO Domain Applied and Engineering Sciences also awarded funding to 35 Take-off projects.
Bridging the gap: aXelerated Large bone defect healing (XLbone) – dr. ir. D. Gawlitta, University Medical Center Utrecht (19260)
Bone is the second most transplanted tissue worldwide. There is an urgent need for the development of a new generation of bone substitutes. Tissue-engineered constructs, consisting of cells, biomaterials and bioactive molecules, can offer a promising alternative. With these, mimicry of the natural pathway for bone formation via a cartilage intermediate is feasible. In this project, the mechanisms will be unraveled that underlie a novel bone regenerative strategy that is based on creating a scalable cartilage template. Also, we will generate a proof of concept for the restoration of large bone defects of clinically relevant size.